Protein name:
Hypoxia-inducible factor 1-alpha inhibitor ;
Alternative:
Hypoxia-inducible factor asparagine hydroxylase ;Factor inhibiting HIF-1 (FIH-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3.
Function:
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAATAAEAVA | SGSGEPREEA | GALGPAWDES | QLRSYSFPTR | PIPRLSQSDP |
100:
RAEELIENEE | PVVLTDTNLV | YPALKWDLEY | LQENIGNGDF | SVYSASTHKF |
150:
LYYDEKKMAN | FQNFKPRSNR | EEMKFHEFVE | KLQDIQQRGG | EERLYLQQTL |
200:
NDTVGRKIVM | DFLGFNWNWI | NKQQGKRGWG | QLTSNLLLIG | MEGNVTPAHY |
250:
DEQQNFFAQI | KGYKRCILFP | PDQFECLYPY | PVHHPCDRQS | QVDFDNPDYE |
300:
RFPNFQNVVG | YETVVGPGDV | LYIPMYWWHH | IESLLNGGIT | ITVNFWYKGA |
349:
PTPKRIEYPL | KAHQKVAIMR | NIEKMLGEAL | GNPQEVGPLL | NTMIKGRYN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Hypoxia-inducible factor 1-alpha inhibitor
ELISA Kit for Human Hypoxia-inducible factor 1-alpha inhibitor
CLIA Kit for Human Hypoxia-inducible factor 1-alpha inhibitor
CLIA Kit for Human Hypoxia-inducible factor 1-alpha inhibitor
Polyclonal Antibody for Human Hypoxia-inducible factor 1-alpha inhibitor
Polyclonal Antibody for Human Hypoxia-inducible factor 1-alpha inhibitor
Monoclonal Antibody for Human Hypoxia-inducible factor 1-alpha inhibitor
Monoclonal Antibody for Human Hypoxia-inducible factor 1-alpha inhibitor
Protein for Human Hypoxia-inducible factor 1-alpha inhibitor
Protein for Human Hypoxia-inducible factor 1-alpha inhibitor
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Signet-ring cell carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Muscle .
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-349
tissue :
Melanoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;FUNCTION;MUTAGENESIS OF HIS-199 AND ASP-201
8.
"Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family."
Hewitson K.S.
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McNeill L.A.
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Riordan M.V.
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Tian Y.-M.
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Bullock A.N.
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Welford R.W.
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Elkins J.M.
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J. Biol. Chem.277:26351-26355(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DIMERIZATION;MASS SPECTROMETRY;MUTAGENESIS OF LEU-340 AND ILE-344
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
12.
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Proc. Natl. Acad. Sci. U.S.A.103:14767-14772(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NFKB1 AND NFKBIA
13.
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more...
Proc. Natl. Acad. Sci. U.S.A.105:3368-3373(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PPP1R12A
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH APBA3;SUBCELLULAR LOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBE3A
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
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Lasa M.
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Polevoda B.
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Gazquez C.
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Elosegui-Artola A.
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Kim D.S.
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De Juan-Pardo E.
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Hole K.
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Larrea E.
,
Timmerman E.
,
Prieto J.
,
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,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH IRON AND 2-OXOGLUTARATE;SUBUNIT
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH 786-826 OF HIF1A; IRON; ZINC AND 2-OXOGLUTARATE
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS);SUBUNIT
24.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH IRON AND INHIBITOR
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH IRON; SUCCINATE AND FUMARATE
26.
"Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor."
Coleman M.L.
,
McDonough M.A.
,
Hewitson K.S.
,
Coles C.
,
Mecinovic J.
,
Edelmann M.
,
Cook K.M.
,
Cockman M.E.
,
Lancaster D.E.
,
Kessler B.M.
,
Oldham N.J.
,
Ratcliffe P.J.
,
Schofield C.J.
J. Biol. Chem.282:24027-24038(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEXES WITH 1930-1949 OR 1997-2016 OF MOUSE NOTCH1; IRON AND 2-OXOGLUTARATE;FUNCTION;SUBUNIT
27.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 11-349 OF MUTANTS ALA-201 AND GLY-201 IN COMPLEXES WITH 786-826 OR 788-806 OF HIF1A; IRON OR ZINC AND 2-OXOGLUTARATE;MUTAGENESIS OF ASP-201; TRP-296 AND LEU-340
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) IN COMPLEX WITH IRON AND 2-OXOGLUTARATE ANALOGS
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 15-349 IN COMPLEX WITH IRON AND QUINOL FAMILY INHIBITORS
30.
"The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases."
Chowdhury R.
,
Yeoh K.K.
,
Tian Y.M.
,
Hillringhaus L.
,
Bagg E.A.
,
Rose N.R.
,
Leung I.K.
,
Li X.S.
,
Woon E.C.
,
Yang M.
,
McDonough M.A.
,
King O.N.
,
Clifton I.J.
,
Klose R.J.
,
Claridge T.D.
,
Ratcliffe P.J.
,
Schofield C.J.
,
Kawamura A.
EMBO Rep.12:463-469(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH IRON AND INHIBITORS
31.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) IN COMPLEX WITH IRON; 2-OXOGLUTARATE AND 538-558 OF TNKS2;FUNCTION
32.
"Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor."
Yang M.
,
Ge W.
,
Chowdhury R.
,
Claridge T.D.
,
Kramer H.B.
,
Schmierer B.
,
McDonough M.A.
,
Gong L.
,
Kessler B.M.
,
Ratcliffe P.J.
,
Coleman M.L.
,
Schofield C.J.
J. Biol. Chem.286:7648-7660(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF MUTANT HIS-239 IN COMPLEX WITH ZINC; N-OXALYLGLYCINE AND PEPTIDE SUBSTRATE;FUNCTION;INTERACTION WITH ANK1;MUTAGENESIS OF ASP-201 AND GLN-239